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Woeckel, M. ; Rospleszcz, S. ; Wolf, K. ; Breitner-Busch, S. ; Ingrisch, M.* ; Bamberg, F.* ; Ricke, J.* ; Schlett, C.L.* ; Storz, C.* ; Schneider, A.E. ; Stoecklein, S.* ; Peters, A.

Association between long-term exposure to traffic-related air pollution and cardio-metabolic phenotypes: An MRI data-based analysis.

Environ. Sci. Technol. 58, 18064-18075 (2024)
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Long-term exposure to traffic-related air pollution (TRAP) is associated with cardiometabolic disease; however, its role in subclinical stages of disease development is unclear. Thus, we aimed to explore this association in a cross-sectional analysis, with cardiometabolic phenotypes derived from magnetic resonance imaging (MRI). Phenotypes of the left (LV) and right cardiac ventricle, whole-body adipose tissue (AT), and organ-specific AT were obtained by MRI in 400 participants of the KORA cohort. Land-use regression models were used to estimate residential long-term exposures to TRAP, e.g., nitrogen dioxides (NO2) or particle number concentration (PNC). Associations between TRAP and MRI phenotypes were modeled using linear regression. Participants' mean age was 56 ± 9 years, and 42% were female. Long-term exposure to TRAP was associated with decreased LV wall thickness; a 6.0 μg/m3 increase in NO2 was associated with a -1.9% [95% confidence interval: -3.7%; -0.1%] decrease in mean global LV wall thickness. Furthermore, we found associations between TRAP and increased cardiac AT. A 2,242 n/cm3 increase in PNC was associated with a 4.3% [-1.7%; 10.4%] increase in mean total cardiac AT. Associations were more pronounced in women and in participants with diabetes. Our exploratory study indicates that long-term exposure to TRAP is associated with subclinical cardiometabolic disease states, particularly in metabolically vulnerable subgroups.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cardiometabolic Disease ; Cross-sectional Study ; Magnetic Resonance Imaging ; Traffic-related Air Pollution ; Ultrafine Particles; Particulate Matter Exposure; Residential Proximity; Major Roadways; Heart; Population; Pm2.5; Particles; Disease; Models; Kora
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0013-936X
e-ISSN 1520-5851
Journal Environmental Science & Technology
Quellenangaben Volume: 58, Issue: 41, Pages: 18064-18075 Article Number: , Supplement: ,
Publisher ACS
Publishing Place Washington, DC
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504000-001
G-504090-001
Grants Siemens Healthcare
German Centre for Cardiovascular Disease Research (Berlin, Germany)
Centre for Diabetes Research (DZD e.V., Neuherberg, Germany)
German Research Foundation (DFG, Deutsche Forschungsgemeinschaft)
State of Bavaria
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
DOI 10.1021/acs.est.4c03163
WOS ID 001330039800001
Scopus ID 85205756742
PubMed ID 39365792
Erfassungsdatum 2024-10-05
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