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CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.
Oncotarget 2, 970-975 (2011)
Predicting the clinical course of osteosarcoma patients is a crucial prerequisite for a better treatment stratification in these highly aggressive neoplasms of bone. In search of new and reliable biomarkers we recently identified cysteine-rich intestinal protein 1 (CRIP1) to have significant prognostic impact in gastric cancer and therefore decided to investigate its role also in osteosarcoma. For this purpose we analyzed 223 pretherapeutic and well characterized osteosarcoma samples for their immunohistochemical expression of CRIP1 and correlated our findings with clinico-pathological parameters including follow‑up, systemic spread and response to chemotherapy. Interestingly and contrarily to gastric cancer, we found CRIP1 expression more frequently in patients with long‑term survival (10-year survival 73% in positive vs. 54% in negative cases, p = 0.0433) and without metastases (p = 0.0108) indicating a favorable prognostic effect. CRIP1 therefore seems to represent a promising new biomarker in osteosarcoma patients which should be considered for a prospective validation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Osteosarcoma; cysteine-rich intestinal protein 1; CRIP1; prognosis; metastases
ISSN (print) / ISBN
1949-2553
e-ISSN
1949-2553
Journal
OncoTarget
Quellenangaben
Volume: 2,
Issue: 12,
Pages: 970-975
Publisher
Impact Journals LLC
Non-patent literature
Publications
Reviewing status
Peer reviewed