PuSH - Publication Server of Helmholtz Zentrum München: Effect of a novel food rich in miraculin on the oral microbiome of malnourished oncologic patients with dysgeusia.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Plaza-Díaz, J.* ; Ruiz Ojeda, F.J. ; López-Plaza, B.* ; Brandimonte-Hernández, M.* ; Álvarez-Mercado, A.I.* ; Arcos-Castellanos, L.* ; Feliú-Batlle, J.* ; Hummel, T.* ; Palma-Milla, S.* ; Gil, A.*

Effect of a novel food rich in miraculin on the oral microbiome of malnourished oncologic patients with dysgeusia.

Cancers 16:3414 (2024)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

BACKGROUND/OBJECTIVES: Dysgeusia contributes to the derangement of nutritional status in patients with cancer as well as worsening the quality of life. There has been a lack of effective treatments for taste disorders provided by the pharmaceutical industry. METHODS: This was a pilot randomized, parallel, triple-blind, and placebo-controlled intervention clinical trial in which 31 malnourished patients with cancer and dysgeusia receiving antineoplastic treatment were randomized into three arms [standard dose of DMB (150 mg DMB/tablet), high dose of DMB (300 mg DMB/tablet) or placebo (300 mg freeze-dried strawberry)] for three months. Patients consumed a DMB or placebo tablet before each main meal. Using the nanopore methodology, we analyzed the oral microbiome of patients with cancer using saliva samples. RESULTS: All patients with cancer and dysgeusia had dysbiosis in terms of lower bacterial diversity and richness. DMB consumption was associated with changes in oral microbiome composition. Neither selected bacteria nor taste perception, type of diet, and cytokine levels were associated with mucositis. Likewise, alcohol and tobacco consumption as well as general and digestive toxicity due to systemic therapy were not associated with specific changes of the oral microbiome, according to logistic binary regression. The standard dose of DMB resulted in a lower abundance of Veillonella compared with the high DMB dose and placebo at 3 months after intervention with DMB. In particular, some species such as Streptococcus parasanguinis, Veillonella parvula, and Streptococcus mutans were less abundant in the DMB standard-dose group. Additionally, the consumption of a standard dose of DMB revealed a negative association between the concentrations of TNF-α and the abundance of species such as Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus dysgalactiae and Streptococcus agalactiae. CONCLUSIONS: Accordingly, regular DMB consumption could modify the oral microbiome in patients with cancer and dysgeusia, which may contribute to maintaining an appropriate immune response. However, as the present pilot study involved a small number of participants, further studies are necessary to draw robust conclusions from the data.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cancer ; Dried Miracle Berries ; Dysgeusia ; Malnutrition ; Neoplasms ; Oral Microbiome ; Taste Disorders; Patients Receiving Chemotherapy; Cancer-patients; Porphyromonas-gingivalis; Taste Alterations; Health; Mechanism; Radiation; Disease; Complex

ISSN (print) / ISBN 2072-6694

Journal Cancers

Quellenangaben Volume: 16, Issue: 19, Article Number: 3414

Publisher MDPI

Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)

Grants Cervera" Transfer RD Projects
Medicinal Gardens S.L. through the Center for Industrial Technological Development (CDTI)