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Scherag, A.* ; Kleber, M.* ; Boes, T.* ; Kolbe, A.L.* ; Ruth, A.* ; Grallert, H. ; Illig, T. ; Heid, I.M. ; GIANT Consortium (Gieger, C. ; Thiering, E. ; Meitinger, T. ; Heinrich, J. ; Peters, A. ; Wichmann, H.-E. ; Illig, T. ; Grallert, H.) ; Toschke, A.M.* ; Grau, K.* ; NUGENOB Consortium (*) ; Sørensen, T.I.* ; Hebebrand, J.* ; Hinney, A.* ; Reinehr, T.*

SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents.

Obesity 20, 466-470 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P < 10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Body-mass index; Follow-up; Association; RS9939609; German; Loci; Gene; Diet; FTO
ISSN (print) / ISBN 1930-7381
e-ISSN 1930-739X
Journal Obesity
Quellenangaben Volume: 20, Issue: 2, Pages: 466-470 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)