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Kübler, I.C.* ; Kretzschmar, J.* ; Arredondo-Lasso, M.N.* ; Keeley, S.D.* ; Rößler, L.C.* ; Ganß, K. ; Sandoval-Guzmán, T. ; Brankatschk, M.*

Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum.

npj Reg. Med. 9:33 (2024)

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In regenerating tissues, synthesis and remodeling of membranes rely on lipid turnover and transport. Our study addresses lipid adaptations in intestinal regeneration of Drosophila melanogaster and limb regeneration of Ambystoma mexicanum. We found changes in lipid profiles at different locations: transport, storage organs and regenerating tissues. We demonstrate that attenuating insulin signaling, exclusively in fat storage, inhibits the regeneration-specific response in both the fat storage and the regenerating tissue in Drosophila. Furthermore, in uninjured axolotls we found sex-specific lipid profiles in both storage and circulation, while in regenerating animals these differences subside. The regenerating limb presents a unique sterol profile, albeit with no sex differences. We postulate that regeneration triggers a systemic response, where organs storing lipids play a significant role in the regulation of systemic lipid traffic. Second, that this response may be an active and well-regulated mechanism, as observed when homeostatic sex-differences disappear in regenerating salamanders.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Lipoprotein Particles; Expression Analysis; Limb Regeneration; Murine Model; Sex; Insulin; Growth; Transcriptome; Mechanisms; Evolution

ISSN (print) / ISBN 2057-3995

e-ISSN 2057-3995

Journal npj Regenerative Medicine

Quellenangaben Volume: 9, Issue: 1, Article Number: 33

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Pancreatic Islet Research (IPI)

Grants FOSTER studentship of the TU Dresden
German research foundation
Medical Research Council, as part of UK Research and Innovation
MRC LMB PhD studentship