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Geyer, P.E.* ; Hornburg, D.* ; Pernemalm, M.* ; Hauck, S.M. ; Palaniappan, K.K.* ; Albrecht, V.* ; Dagley, L.F.* ; Moritz, R.L.* ; Yu, X.* ; Edfors, F.* ; Vandenbrouck, Y.* ; Mueller-Reif, J.B.* ; Sun, Z.* ; Brun, V.* ; Ahadi, S.* ; Omenn, G.S.* ; Deutsch, E.W.* ; Schwenk, J.M.*

The circulating proteome─technological developments, current challenges, and future trends.

J. Proteome Res. 23, 5279-5295 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest in using these novel methods for studying the circulating proteome, as blood offers an accessible window into human health. However, every methodological innovation and analytical progress calls for reassessing our existing approaches and routines to ensure that the new data will add value to the greater biomedical research community and avoid previous errors. As representatives of HUPO's Human Plasma Proteome Project (HPPP), we present our 2024 survey of the current progress in our community, including the latest build of the Human Plasma Proteome PeptideAtlas that now comprises 4608 proteins detected in 113 data sets. We then discuss the updates of established proteomics methods, emerging technologies, and investigations of proteoforms, protein networks, extracellualr vesicles, circulating antibodies and microsamples. Finally, we provide a prospective view of using the current and emerging proteomics tools in studies of circulating proteins.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Ptm ; Peptideatlas ; Affinity ; Biomarker Discovery ; Blood ; Extracellular Vesicle ; Mass Spectrometry ; Microsampling ; Plasma ; Serum; Human Plasma Proteome; Biomarker Discovery; Mass-spectrometry; Proteogenomic Characterization; Serum-proteins; Glycosylation; Genetics; Health; Assay; Associations
ISSN (print) / ISBN 1535-3893
e-ISSN 1535-3907
Journal Journal of Proteome Research
Quellenangaben Volume: 23, Issue: 12, Pages: 5279-5295 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Publishing Place 1155 16th St, Nw, Washington, Dc 20036 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CF Metabolomics & Proteomics (CF-MPC)
Grants Knut and Alice Wallenberg Foundation
National Institutes of Health
German Ministry for Science and Education funding action CLINS-PECT-M
National Science Foundation
Max Planck Society