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Open Access Green as soon as Postprint is submitted to ZB.
The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses.
Science 335, 984-989 (2012)
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CHORIOMENINGITIS VIRUS-INFECTION; IL-1-LIKE CYTOKINE IL-33; IN-VIVO; EFFECTOR FUNCTION; IMMUNE-RESPONSES; MICE; EXPRESSION; RECEPTOR; SIGNALS; ST2
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 335,
Issue: 6071,
Pages: 984-989
Publisher
American Association for the Advancement of Science (AAAS)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Hematopoetic Cell Transplants (IMI-KHZ)
Research Unit Gene Vector (AGV)
Research Unit Gene Vector (AGV)