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Berriel Diaz, M. ; Rohm, M. ; Herzig, S.

Cancer cachexia: Multilevel metabolic dysfunction.

Nat. Metab., DOI: 10.1038/s42255-024-01167-9 (2024)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Cancer cachexia is a complex metabolic disorder marked by unintentional body weight loss or 'wasting' of body mass, driven by multiple aetiological factors operating at various levels. It is associated with many malignancies and significantly contributes to cancer-related morbidity and mortality. With emerging recognition of cancer as a systemic disease, there is increasing awareness that understanding and treatment of cancer cachexia may represent a crucial cornerstone for improved management of cancer. Here, we describe the metabolic changes contributing to body wasting in cachexia and explain how the entangled action of both tumour-derived and host-amplified processes induces these metabolic changes. We discuss energy homeostasis and possible ways that the presence of a tumour interferes with or hijacks physiological energy conservation pathways. In that context, we highlight the role played by metabolic cross-talk mechanisms in cachexia pathogenesis. Lastly, we elaborate on the challenges and opportunities in the treatment of this devastating paraneoplastic phenomenon that arise from the complex and multifaceted metabolic cross-talk mechanisms and provide a status on current and emerging therapeutic approaches.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Tumor-necrosis-factor; Cell Lung-cancer; Leukemia Inhibitory Factor; Subcutaneous Adipose-tissue; Promotes Weight-loss; Skeletal-muscle; Double-blind; Energy-expenditure; Factor-alpha; Cachectic Patients
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Publisher Springer
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Grants Edith-Haberland-Wagner Stiftung
Else-Kroner-Fresenius-Stiftung
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme