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Open Access Green: Postprint online available 12/2025
as soon as is submitted to ZB.
Sex differences in insulin induced hippocampus functional connectivity during visual food cue presentation.
J. Clin. Endocrinol. Metab., DOI: 10.1210/clinem/dgae833 (2024)
AIMS: Central insulin has been shown to regulate eating behavior and cognitive processes in a sex-specific manner. Besides memory, the hippocampus is pivotal in the control of appetite. However, how insulin interacts with the hippocampal food cue response and the role of sex hormones in this context remain unclear. METHODS: Using fMRI, we evaluated task-based functional connectivity (FC) of the hippocampus during food cue presentation in 60 participants (age: 21-69; 30 women) after intranasal insulin or placebo administration, in a randomized within-subject design. In an exploratory analysis, we investigated whether hippocampal FC after intranasal insulin administration is related to estradiol and progesterone levels during the follicular and luteal phase of the menstrual cycle in 13 premenopausal women (age: 20-28). RESULTS: Intranasal insulin increased hippocampal FC with the prefrontal cortex compared to placebo, regardless of sex. This correlated with stronger reduction in subjective feeling of hunger and food craving. Moreover, we observed an interaction between sex and nasal spray condition with higher hippocampal FC to the calcarine gyrus after insulin compared to placebo in men, while women showed a lower response. In premenopausal women, the centrally mediated effect of insulin on hippocampus to calcarine gyrus FC negatively correlated with the estradiol/progesterone ratio in the luteal phase. CONCLUSIONS: Central insulin influences hippocampal FC to regions vital for inhibitory control during high-caloric food cue presentation, implying a potential role of the hippocampal network in modulating insulin's anorexic effects. The observed sex differences between the hippocampus and visual cortex might be influenced by sex hormone action.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hippocampus ; Insulin ; Sex ; Fmri; Intranasal Insulin; Menstrual-cycle; Impulse Control; Central Leptin; Young-women; Human Brain; Sensitivity; Hormones; Phase; Activation
ISSN (print) / ISBN
0021-972X
e-ISSN
1945-7197
Publisher
Endocrine Society
Publishing Place
Bethesda, Md.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Obesity (IDO)
Institute of Diabetes and Obesity (IDO)
Grants
China Scholarship Council (CSC)
Deutsche Diabetes Gesellschaft (DDG)
Federal Ministry of Education and Research (BMBF)
Deutsche Diabetes Gesellschaft (DDG)
Federal Ministry of Education and Research (BMBF)