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Rodionov, R.N.* ; Jarzebska, N.* ; Koay, Y.C.* ; Li, M.* ; Kuhn, M.* ; Bornstein, S.R.* ; Martens-Lobenhoffer, J.* ; Eslam, M.* ; Chen, F.W.* ; Rubets, E.* ; Markov, A.G.* ; Weiss, N.* ; Birkenfeld, A.L. ; Schwarz, P.* ; Bode-Böger, S.M.* ; Perakakis, N.* ; O'Sullivan, J.F.* ; George, J.*

Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis.

iScience 27:111366 (2024)

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	Open Access Gold

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There is an unmet need for a biomarker of liver fat. We identified dimethylguanidino valeric acid (DMGV) as a circulating biomarker of liver fat. Here, we assess its two isoforms—symmetric (SDGV) and asymmetric (ADGV)—as biomarkers of steatosis. We determined plasma ADGV, SDGV, related metabolites, alanine aminotransferase (ALT), and the fatty liver index (FLI) in two cohorts and compared their diagnostic performance for liver fat detection. SDGV was the strongest predictor of moderate to severe steatosis. Changes in SDGV correlated with changes in liver fat % in a prospective cohort. In a murine model of fatty liver disease, protein levels and activity of alanine:glyoxylate aminotransferase 2 (AGXT2), which produces SDGV, were increased and coincided with elevation of SDGV concentrations. SDGV is a biomarker of liver fat and its increase in hepatic steatosis results from the upregulation of AGXT2 activity.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Clinical Finding ; Health Sciences ; Physiological State; Fatty Liver; Human Plasma; Enzyme; Quantification; Arginine; Agxt2

ISSN (print) / ISBN 2589-0042

e-ISSN 2589-0042

Journal iScience

Quellenangaben Volume: 27, Issue: 12, Article Number: 111366

Publisher Elsevier

Publishing Place Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)

Grants Cancer Institute, NSW grant
NHMRC-MRFF CVD grant
National Heart Foundation
Federal Ministry of Education and Research (BMBF)
Robert W. Storr Bequest
National Health and Medical Research Council of Australia (NHMRC)
NSW Office of Medical Health and Research