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Rosenberger, A.* ; Bickeböller, H.* ; McCormack, V.* ; Brenner, D.R.* ; Duell, E.J.* ; Tjønneland, A.* ; Friis, S.* ; Muscat, J.E.* ; Yang, P.* ; Wichmann, H.-E. ; Heinrich, J. ; Szeszenia-Dabrowska, N.* ; Lissowska, J.* ; Zaridze, D.* ; Rudnai, P.* ; Fabianova, E.* ; Janout, V.* ; Bencko, V.* ; Brennan, P.* ; Mates, D.* ; Schwartz, A.G.* ; Cote, M.L.* ; Zhang, Z.F.* ; Morgenstern, H.* ; Oh, S.S.* ; Field, J.K.* ; Raji, O.* ; McLaughlin, J.R.* ; Wiencke, J.* ; LeMarchand, L.* ; Neri, M.* ; Bonassi, S.* ; Andrew, A.S.* ; Lan, Q.* ; Hu, W.* ; Orlow, I.* ; Park, B.J.* ; Boffetta, P.* ; Hung, R.J.*

Asthma and lung cancer risk: A systematic investigation by the International Lung Cancer Consortium.

Carcinogenesis 33, 587-597 (2012)
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Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I(2) = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Obstructive pulmonary-disease; Nonmalignant respiratory conditions; United-states; Never-smokers; Nonsmoking women; Family-history; Prospective cohort; Resdential radon; Distinct diseases; Meta-regression
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Journal Carcinogenesis
Quellenangaben Volume: 33, Issue: 3, Pages: 587-597 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
PubMed ID 22198214
DOI 10.1093/carcin/bgr307
WOS ID WOS:000300988100014
Scopus ID 84863279846
Erfassungsdatum 2012-03-28
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