Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
A review focuses on a neglected and controversial component of SCI: Myelin debris.
Front. Immunol. 15:1436031 (2024)
Myelin sheath, as the multilayer dense structure enclosing axons in humans and other higher organisms, may rupture due to various injury factors after spinal cord injury, thus producing myelin debris. The myelin debris contains a variety of myelin-associated inhibitors (MAIs) and lipid, all inhibiting the repair after spinal cord injury. Through summary and analysis, the present authors found that the inhibition of myelin debris can be mainly divided into two categories: firstly, the direct inhibition mediated by MAIs; secondly, the indirect inhibition mediated by lipid such as cholesterol. It is worth noting that phagocytes are required in the latter indirect inhibition, such as professional phagocytes (macrophages et al.) and non-professional phagocytes (astrocytes et al.). Moreover, complement and the immune system also participate in the phagocytosis of myelin debris, working together with phagocytes to aggravate spinal cord injury. In conclusion, this paper focuses on the direct and indirect effects of myelin debris on spinal cord injury, aiming to provide new inspiration and reflection for the basic research of spinal cord injury and the conception of related treatment.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Axon ; Cholesterol ; Foam Cell ; Myelin Debris ; Myelin-associated Inhibitors ; Spinal Cord Injury; Spinal-cord-injury; Receptor Family-member; Nogo Receptor; Axonal Regeneration; Neurite Outgrowth; Cholesterol Accumulation; Inhibitory-activity; Cns Remyelination; Messenger-rna; White-matter
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 15,
Article Number: 1436031
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Regenerative Biology (IRBM)
Grants
Postgraduate Research & Practice Innovation Program of Jiangsu Province
Medical Research Projects of the Health Commission of Jiangsu Province
National Natural Science Foundation of China
Medical Research Projects of the Health Commission of Jiangsu Province
National Natural Science Foundation of China