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Zhou, Y.* ; Xu, T.* ; Han, W. ; Wu, Z.* ; Yang, C.* ; Chen, X.*

A review focuses on a neglected and controversial component of SCI: Myelin debris.

Front. Immunol. 15:1436031 (2024)
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Myelin sheath, as the multilayer dense structure enclosing axons in humans and other higher organisms, may rupture due to various injury factors after spinal cord injury, thus producing myelin debris. The myelin debris contains a variety of myelin-associated inhibitors (MAIs) and lipid, all inhibiting the repair after spinal cord injury. Through summary and analysis, the present authors found that the inhibition of myelin debris can be mainly divided into two categories: firstly, the direct inhibition mediated by MAIs; secondly, the indirect inhibition mediated by lipid such as cholesterol. It is worth noting that phagocytes are required in the latter indirect inhibition, such as professional phagocytes (macrophages et al.) and non-professional phagocytes (astrocytes et al.). Moreover, complement and the immune system also participate in the phagocytosis of myelin debris, working together with phagocytes to aggravate spinal cord injury. In conclusion, this paper focuses on the direct and indirect effects of myelin debris on spinal cord injury, aiming to provide new inspiration and reflection for the basic research of spinal cord injury and the conception of related treatment.
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Publication type Article: Journal article
Document type Review
Keywords Axon ; Cholesterol ; Foam Cell ; Myelin Debris ; Myelin-associated Inhibitors ; Spinal Cord Injury; Spinal-cord-injury; Receptor Family-member; Nogo Receptor; Axonal Regeneration; Neurite Outgrowth; Cholesterol Accumulation; Inhibitory-activity; Cns Remyelination; Messenger-rna; White-matter
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 15, Issue: , Pages: , Article Number: 1436031 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
Grants Postgraduate Research & Practice Innovation Program of Jiangsu Province
Medical Research Projects of the Health Commission of Jiangsu Province
National Natural Science Foundation of China
DOI 10.3389/fimmu.2024.1436031
WOS ID 001370531000001
Scopus ID 85210994355
PubMed ID 39650659
Erfassungsdatum 2024-12-10
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