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Mullenders, L.* ; Atkinson, M.J. ; Paretzke, H.G. ; Sabatier, L.* ; Bouffler, S.*

Assessing cancer risks of low-dose radiation.

Nat. Rev. Cancer 9, 596-604 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.
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Publication type Article: Journal article
Document type Review
Keywords atomic-bomb survivors; double-strand breaks; ionizing-radiation; dna-damage; in-vivo; gene-expression; hyper-radiosensitivity; telomere dysfunction; human-cells; interventional radiology
Language english
Publication Year 2009
HGF-reported in Year 2009
ISSN (print) / ISBN 1474-175X
e-ISSN 1474-1768
Journal Nature Reviews - Cancer
Quellenangaben Volume: 9, Issue: 8, Pages: 596-604 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
Institute of Radiation Protection (ISS)
POF-Topic(s) 30202 - Environmental Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
G-501100-004
DOI 10.1038/nrc2677
Scopus ID 67749103618
PubMed ID 19629073
Erfassungsdatum 2009-11-20
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