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Open Access Green as soon as Postprint is submitted to ZB.
Looking into eyes: Rhodopsin pathologies in Drosophila.
Adv. Exp. Med. Biol. 723, 415-423 (2012)
The detailed examination of eye structure and function in numerous Drosophila mutants has provided unprecedented insights into retinal physiology and pathology. Many Drosophila mutants that undergo retinal degeneration (RD) exhibit structural and/or dynamic alterations of the photon receptor rhodopsin, and similar defects cause retinitis pigmentosa (RP) in humans. Here, we consider how the use of Drosophila has advanced our understanding of RP and highlight new mechanisms underlying rhodopsin-mediated pathologies in the retina.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Retinitis pigmentosa; Retinal degeneration; Rhodopsin; Drosophila; Photoreceptor; Retina; Phototransduction; Autophagy; ER stress
ISSN (print) / ISBN
0065-2598
ISBN
978-1-4614-0630-3
Quellenangaben
Volume: 723,
Issue: 6,
Pages: 415-423
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CF Metabolomics & Proteomics (CF-MPC)