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Aljabali, S. M. ; Pai, S. ; Teperino, R.

Paternal impact on the developmental programming of sexual dimorphism.

Front. Cell Dev. Biol. 12:1520783 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Sexual dimorphism involves distinct anatomical, physiological, behavioral, and developmental differences between males and females of the same species, influenced by factors prior to conception and during early development. These sex-specific traits contribute to varied phenotypes and individual disease risks within and across generations and understanding them is essential in mammalian studies. Hormones, sex chromosomes, and imprinted genes drive this dimorphism, with over half of quantitative traits in wildtype mice showing sex-based variation. This review focuses on the impact of paternal non-genetic factors on sexual dimorphism. We synthesize current research on how paternal health before conception affects offspring phenotypes in a sex-specific manner, examining mechanisms such as DNA methylation, paternally imprinted genes, sperm RNA, and seminal plasma. Additionally, we explore how paternal influences indirectly shape offspring through maternal behavior, uterine environment, and placental changes, affecting males and females differently. We propose mechanisms modulating sexual dimorphism during development, underscoring the need for sex-specific documentation in animal studies.
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Publication type Article: Journal article
Document type Review
Keywords Developmental Programing ; Epigenetics ; Imprinting ; Paternal Inheritance ; Seminal Plasma ; Sexual Dimoprhism ; Sperm Rnas; X-chromosome Inactivation; Epigenetic Inheritance; Stress; Expression; Exposure; Brain; Responses; Obesity; Traits; Model
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2296-634X
e-ISSN 2296-634X
Journal Frontiers in cell and developmental biology
Quellenangaben Volume: 12, Issue: , Pages: , Article Number: 1520783 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500693-001
Grants Fritz-Thyssen Foundation
DAAD (German Academic Exchange Service)
German Center for Diabetes Research
Helmholtz Munich
DOI 10.3389/fcell.2024.1520783
WOS ID 001380295800001
Scopus ID 85212584764
PubMed ID 39712575
Erfassungsdatum 2024-12-20
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