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Pacheco Da Silva, E.* ; Weinmann, T.* ; Gerlich, J.* ; Weinmayr, G.* ; Genuneit, J.* ; Nowak, D.* ; von Mutius, E. ; Vogelberg, C.* ; Radon, K.* ; Förster, F.*

Exposure profiles for the long-term use of disinfectants and cleaning products and asthma.

Allergy, DOI: 10.1111/all.16456 (2024)
Publ. Version/Full Text DOI PMC
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BACKGROUND: Using disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long-term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma. METHODS: LCA was conducted on data from 1143 young adults initially recruited in the German centers of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and followed up three times. In our LCA model, we included the use of cleaning sprays, disinfectant sprays, and nonspray disinfection methods, measured at ages 19-24 (first assessment) and 29-34 years (second assessment). Associations between identified exposure profiles and current as well as incident asthma/wheeze were evaluated by logistic regression. RESULTS: We identified five long-term exposure profiles to DCPs (latent classes): no weekly use of DCPs (55% of participants), use in first assessment (7%), use in second assessment (18%), persistent use (8%), and persistent cleaning sprays use (12%). Compared to "no weekly use," being in the "persistent use" profile was associated with both current asthma (OR = 1.68, 95% CI = [0.48-5.88]) and current wheeze (OR = 1.71, 95% CI = [0.75-3.90]). For incident asthma/wheeze, interval estimates were very wide. CONCLUSIONS: Our study identified five distinct long-term exposure profiles to DCPs. Among those, only a persistent weekly use of multiple DCPs over time seemed to have an adverse effect on asthma. However, large confidence intervals indicate considerable uncertainty.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Asthma ; Disinfectants And Cleaning Products ; Exposure Profiles ; Latent Class Analysis ; Sprays; Health-care; Occupational-exposure; Sprays; Nurses; Agents; Risk
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
Grants German Federal Institute for Occupational Safety and Health
German Ministry for Economy and Labour
European Respiratory Society
Société de Pneumologie de Langue Française
German Ministry of Labour and Social Affairs
Deutsche Forschungsgemeinschaft