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Why are we still in need for novel anti-obesity medications?

Lancet Reg. Health-Eur. 47:101098 (2024)
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From the pioneering moment in 1987 when the insulinotropic effect of glucagon-like peptide 1 (GLP-1) was first demonstrated in humans, to today's pharmaceutical gold rush for GLP-1-based treatments of obesity, the journey of GLP-1 pharmacology has been nothing short of extraordinary. The sequential conceptual developments of long-acting GLP-1 receptor (GLP-1R) mono-agonists, GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual-agonists, and GLP-1R/GIPR/glucagon receptor (GcgR) triple agonists, have led to profound body weight-lowering capacities, with benefits that extend past obesity and towards obesity-associated diseases. The GLP-1R/GIPR dual-agonist tirzepatide has demonstrated a remarkable 23% body weight reduction in individuals with obesity over 72 weeks, eclipsing the average result achieved by certain types of bariatric surgery. Meanwhile, the GLP-1R/GIPR/GcgR triple-agonist retatrutide achieves similar body weight loss (∼25%) in just two-thirds of the time, potentially surpassing the efficacy of Roux-en-Y gastric bypass. These remarkable achievements rightfully raise the question whether and why there is still need for novel anti-obesity medications (AOMs) in the future.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Anti-obesity Medication (aom) ; Diabetes ; Gip ; Glp-1 ; Obesity; Peptide-1 Receptor Agonists; Glucagon; Delivery; Nausea
ISSN (print) / ISBN 2666-7762
e-ISSN 2666-7762
Quellenangaben Volume: 47, Issue: , Pages: , Article Number: 101098 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Non-patent literature Publications
Reviewing status Peer reviewed
Grants German Center for Diabetes Research (DZD e.V.)
German Research Foundation
European Union