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Semmler-Behnke, M. ; Kreyling, W.G. ; Schulz, H. ; Takenaka, S. ; Butler, J.P.* ; Henry, F.S.* ; Tsuda, A.*

Nanoparticle delivery in infant lungs.

Proc. Natl. Acad. Sci. U.S.A. 109, 5092-5097 (2012)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The lung surface is an ideal pathway to the bloodstream for nanoparticle-based drug delivery. Thus far, research has focused on the lungs of adults, and little is known about nanoparticle behavior in the immature lungs of infants. Here, using nonlinear dynamical systems analysis and in vivo experimentation in developing animals, we show that nanoparticle deposition in postnatally developing lungs peaks at the end of bulk alveolation. This finding suggests a unique paradigm, consistent with the emerging theory that as alveoli form through secondary septation, alveolar flow becomes chaotic and chaotic mixing kicks in, significantly enhancing particle deposition. This finding has significant implications for the application of nanoparticle-based inhalation therapeutics in young children with immature lungs from birth to 2 y of age.
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Publication type Article: Journal article
Document type Scientific Article
Keywords postnatal lung development; inhalation therapy; pulmonary acinus; aerosol transport and deposition; convective mixing
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 109, Issue: 13, Pages: 5092-5097 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)