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Physiologische und pathophysiologische Veränderungen der alternden Lunge.
Physiological and pathophysiological changes of the ageing lung.
Z. Gerontol. Geriatr. 58, 85-90 (2025)
BACKGROUND: Due to age-related changes the lung function decreases. At the same time there is an increase in pulmonary diseases that lead to restrictions in mobility and autonomy. RESEARCH QUESTION: What are the underlying changes in lung ageing? To what extent do they affect lung function and are there factors that can be influenced? METHOD: Literature search. RESULTS: Ageing of the lungs is associated with a loss of elasticity and distensibility. Senescence-associated factors play an important role at the molecular level. Accumulation of damaged DNA and proteins, oxidative stress and chronic inflammation are major factors. Avoidance of harmful environmental factors can reduce the disease burden. CONCLUSION: Age-related pathophysiological changes lead to increased work of breathing with decreasing muscle strength. Patients should be encouraged to avoid inhaling noxious agents as these are associated with a diminution of lung function loss even in older age.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cellular Senescence ; Infammation ; Mitochondrial Dysfunction ; Oxidative Stress ; Work Of Breathing; Cellular Senescence; Consequences; Dysfunction; Phenotype; Mechanism; Hallmarks
ISSN (print) / ISBN
0948-6704
e-ISSN
1435-1269
Quellenangaben
Volume: 58,
Issue: 2,
Pages: 85-90
Publisher
Springer
Publishing Place
Heidelberg
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)