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Matta Pereira, L. ; Weber, P. ; Erener, S. ; Walth-Hummel, A.A. ; Hass, D, ; Bühler, L. ; Klepac, K. ; Szendroedi, J. ; Garcia Guerra, J.F. ; Rohm, M. ; Sterr, M. ; Lickert, H. ; Bartelt, A. ; Herzig, S.

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice.

Cell Rep. 44:115225 (2025)
Publ. Version/Full Text Research data DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual's age is unclear. Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. Short-term IF improves glucose homeostasis across all age groups without altering islet function and morphology. In contrast, while chronic IF is beneficial for adult mice, it results in impaired β cell function in the young. Using single-cell RNA sequencing (scRNA-seq), we delineate that the β cell maturation and function scores are reduced in young mice. In human islets, a similar pattern is observed in type 1 (T1D), but not type 2 (T2D), diabetes, suggesting that the impact of chronic IF in adolescence is linked to the development of β cell dysfunction. Our study suggests considering the duration of IF in younger persons, as it may worsen rather than reduce diabetes outcomes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cp: Metabolism ; Langerhans’ Islets ; Diabetes ; Glucose Metabolism ; Insulin ; Intermittent Fasting ; Pancreas ; Weight Loss ; β Cells; Body-weight; Health; Mechanisms
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 44, Issue: 2, Pages: , Article Number: 115225 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Regeneration Research (IDR)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
G-501900-250
G-502591-001
G-501900-257
G-501900-231
G-502300-001
Grants Helmholtz Future Topic AMPro
DFG
Deutsches Zentrum fur Herz-Kreislaufforschung (DZHK)
European Research Training Group (ERC) Starting Grant PROTEOFIT
European Research Council (ERC) under the European Union
German Diabetes Center (DZD) Next grant
DOI 10.1016/j.celrep.2024.115225
WOS ID 001402743800001
Scopus ID 85215099463
PubMed ID 39827461
Erfassungsdatum 2025-03-24
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