PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Marquez, M.* ; Huyvaert, M.* ; Perry, J.R.* ; Pearson, R.D.* ; Falchi, M.* ; Morris, A.P.* ; Vivequin, S.* ; Lobbens, S.* ; Yengo, L.* ; Gaget, S.* ; Pattou, F.* ; Poulain-Godefroy, O.* ; Charpentier, G.* ; Carlsson, L.M.* ; Jacobson, P.* ; Sjöström, L.* ; Lantieri, O.* ; Heude, B.* ; Walley, A.* ; Balkau, B.* ; Marre, M.* ; Froguel, P.* ; Cauchi, S* ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.)

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.

Diabetes 61, 524-530 (2012)
Publ. Version/Full Text Volltext DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
8.286
2.266
11
13
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords GENOME-WIDE ASSOCIATION; INSULIN-RECEPTOR GENE; BETA-CELL FUNCTION; RARE VARIANTS; COMPLEX DISEASES; MELLITUS; TRAITS; SUSCEPTIBILITY; RESISTANCE; TRANSCRIPTION
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 61, Issue: 2, Pages: 524-530 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504200-002
G-504100-001
G-503900-001
G-500700-001
PubMed ID 22210315
DOI 10.2337/db11-0728
WOS ID WOS:000299798100031
Erfassungsdatum 2012-04-23
[➜Report correction]