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Pollastri, A. ; Kovacs, P.* ; Keller, M.

Circulating cell-free DNA in metabolic diseases.

J. Endocr. Soc. 9:bvaf006 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Metabolic diseases affect a consistent part of the human population, leading to rising mortality rates. This raises the need for diagnostic tools to monitor the progress of these diseases. Lately, circulating cell-free DNA (cfDNA) has emerged as a promising biomarker for various metabolic diseases, including obesity, type 2 diabetes, and metabolic-associated fatty liver disease. CfDNA is released from apoptotic and necrotic cells into the bloodstream and other body fluids, and it retains various molecular signatures of its tissue of origin. Thus, cfDNA load and composition can reflect tissue pathologies and systemic metabolic dysfunctions. In addition to its potential as a diagnostic biomarker, interest in cfDNA derives from its recently discovered role in adipose tissue inflammation in obesity. This review discusses detection methods and clinical significance of cfDNA in metabolic diseases.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Mafld ; Cell-free Dna ; Diabetes ; Epigenetics ; Obesity; Cancer-patients; Plasma; Death; Serum; Inflammation; Obesity; Origin
ISSN (print) / ISBN 2472-1972
e-ISSN 2472-1972
Journal Journal of the Endocrine Society
Quellenangaben Volume: 9, Issue: 2, Pages: , Article Number: bvaf006 Supplement: ,
Publisher Endocrine Society
Publishing Place 2055 L St Nw, Suite 600, Washington, Dc 20036 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants Deutsches Zentrum fur Diabetesforschung (DZD)
Deutsche Diabetes Gesellschaft
Deutsche Forschungsgemeinschaft for a Collaborative Research Center