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Luzius, T. ; Jeske, S. ; Baer, J.* ; Goelnitz, U.* ; Protzer, U. ; Wettengel, J.M.

A multiplex polymerase chain reaction assay for the detection of herpes simplex virus, cytomegalovirus, and varicella-zoster virus in cerebrospinal Fluid.

Microorganisms 13:111 (2025)

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Viral meningitis poses a significant clinical challenge due to its rapid onset and potential progression to life-threatening encephalitis. Early detection of treatable viral pathogens such as Herpes simplex virus (HSV), Cytomegalovirus (CMV), and Varicella-zoster virus (VZV) is essential for initiating appropriate therapies. However, multiplex PCRs for the rapid and simultaneous detection of these pathogens are scarce due to the complex PCR design and the elaborate validation process using cerebrospinal fluid samples. In this study, we established and validated a novel multiplex PCR assay for detecting HSV, CMV, and VZV in cerebrospinal fluid samples and implemented the assay on a fully automated platform.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Clinical Virology ; Multiplex Pcr ; Viral Meningitis

ISSN (print) / ISBN 2076-2607

e-ISSN 2076-2607

Journal Microorganisms

Quellenangaben Volume: 13, Issue: 1, Article Number: 111

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)