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Luzius, T. ; Jeske, S. ; Baer, J.* ; Goelnitz, U.* ; Protzer, U. ; Wettengel, J.M.

A multiplex polymerase chain reaction assay for the detection of herpes simplex virus, cytomegalovirus, and varicella-zoster virus in cerebrospinal Fluid.

Microorganisms 13:111 (2025)
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Viral meningitis poses a significant clinical challenge due to its rapid onset and potential progression to life-threatening encephalitis. Early detection of treatable viral pathogens such as Herpes simplex virus (HSV), Cytomegalovirus (CMV), and Varicella-zoster virus (VZV) is essential for initiating appropriate therapies. However, multiplex PCRs for the rapid and simultaneous detection of these pathogens are scarce due to the complex PCR design and the elaborate validation process using cerebrospinal fluid samples. In this study, we established and validated a novel multiplex PCR assay for detecting HSV, CMV, and VZV in cerebrospinal fluid samples and implemented the assay on a fully automated platform.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Clinical Virology ; Multiplex Pcr ; Viral Meningitis
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2076-2607
e-ISSN 2076-2607
Journal Microorganisms
Quellenangaben Volume: 13, Issue: 1, Pages: , Article Number: 111 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
G-502799-701
DOI 10.3390/microorganisms13010111
Scopus ID 85216069136
PubMed ID 39858879
Erfassungsdatum 2025-03-25
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