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Boraska, V.* ; Day-Williams, A.* ; Franklin, C.S.* ; Elliott, K.S.* ; Panoutsopoulou, K.* ; Tachmazidou, I.* ; Albrecht, E. ; Bandinelli, S.* ; Beilin, L.J.* ; Bochud, M.* ; Cadby, G.* ; Ernst, F.* ; Evans, D.M* ; Hayward, C.* ; Hicks, A.A.* ; Huffman, J.* ; Huth, C. ; James, A.L.* ; Klopp, N. ; Kolcic, I.* ; Kutalik, Z.* ; Lawlor, D.A.* ; Musk, A.W.* ; Pehlic, M.* ; Pennell, C.E.* ; Perry, J.R.* ; Peters, A. ; Polasek, O.* ; Pourcain, B.S.* ; Ring, S.M.* ; Salvi, E.* ; Schipf, S.* ; Staessen, J.A.* ; Teumer, A.* ; Timpson, N.* ; Vitart, V.* ; Warrington, N.M.* ; Yaghootkar, H.* ; Zemunik, T.* ; Zgaga, L.* ; An, P.* ; Anttila, V.* ; Borecki, I.B.* ; Holmen, J.* ; Ntalla, I.* ; Palotie, A.* ; Pietiläinen, K.H.* ; Wedenoja, J.* ; Winsvold, B.S.* ; Dedoussis, G.V.* ; Kaprio, J.* ; Province, M.A.* ; Zwart, J.A.* ; Burnier, M.* ; Campbell, H.* ; Cusi, D.* ; Davey Smith, G.* ; Frayling, T.M.* ; Gieger, C.* ; Palmer, L.J.* ; Pramstaller, P.P.* ; Rudan, I.* ; Völzke, H.* ; Wichmann, H.-E. ; Wright, A.F.* ; Zeggini, E.*

Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts.

PLoS ONE 7:e31369 (2012)

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Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords BODY-FAT DISTRIBUTION; ARM CIRCUMFERENCE; FTO GENE; OBESITY; WOMEN; SEX; MEN; AGE; FAMILIES; STRENGTH

ISSN (print) / ISBN 1932-6203

Journal PLoS ONE

Quellenangaben Volume: 7, Issue: 3, Article Number: e31369

Publisher Public Library of Science (PLoS)

Publishing Place Lawrence, Kan.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)