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Liu, G.* ; Li, S.* ; Deng, B.* ; Huo, L.* ; Bai, H.* ; Jiang, S.* ; Zhou, Y.* ; Pei, Z.* ; Kimna, C. ; Zhao, Y.* ; Xu, L.* ; Li, J.* ; Mu, X.* ; Song, J.*

Phase-separated anisotropic PVA hydrogel loaded with tetramethylpyrazine for spinal cord injury repair.

Chem. Eng. J. 506:159944 (2025)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Spinal cord injury (SCI) is a severe central nervous system disorder that disrupts neural circuit integrity, leading to significant motor and sensory dysfunction or loss. Despite the urgent need, no effective treatments are currently available in clinical practice. Tetramethylpyrazine (TMP), a compound extracted from the plant Ligusticum wallichii, has shown therapeutic potential for SCI, but its efficacy is constrained by the blood-spinal cord barrier and a short half-life. To address this limitation, we developed a polyvinyl alcohol (PVA) hydrogel with an oriented porous structure (TMP/OPH) designed to achieve sustained, localized TMP delivery at the injury site. The TMP/OPH was synthesized via a combined sol–gel transition and freeze-casting method, which enables physical gelation of PVA without additional crosslinking agents, making it a simple, and safe approach that enables the gel to revert to sol upon heating for complete recyclability. TMP/OPH not only functions as a local drug delivery system but also features an anisotropic porous structure that supports axonal regeneration and synaptic reconstruction at the injury site. Mechanistic studies revealed that TMP/OPH, through the sustained TMP release in the early stages of SCI, regulates the TNF signaling pathway, promotes M2 polarization of microglia, suppresses neuroinflammation, and improves the local microenvironment, thus creating favorable conditions for nerve repair. Long-term therapeutic effects, including axonal regeneration, synaptic reconstruction, reduction of glial scar, and improved motor function further support TMP/OPH as a promising therapeutic strategy for SCI repair.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hydrogel ; Polyvinyl Alcohol ; Spinal Cord Injury ; Tetramethylpyrazine; Cell
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1385-8947
Journal Chemical Engineering Journal
Quellenangaben Volume: 506, Issue: , Pages: , Article Number: 159944 Supplement: ,
Publisher Elsevier
Publishing Place Po Box 564, 1001 Lausanne, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505800-001
Grants
Independent research projects conducted by graduate students of Beijing University of Chinese Medicine
Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument
Shenzhen Science and Technology Program
National Natural Science Foundation of China
National Science Fund for Excellent Young Scholars
Central High-Level Traditional Chinese Medicine Hospital Clinical Research Project
DOI 10.1016/j.cej.2025.159944
WOS ID 001421639900001
Scopus ID 85215957490
Erfassungsdatum 2025-03-26
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