Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Tissue clearing and its application in nanoparticle development.
Small:e2410032 (2025)
Nanoparticles are widely used in biomedical applications due to their small size, large surface area, and unique physicochemical properties. These characteristics make them ideal for drug delivery, diagnostic imaging, and therapeutic interventions. Their ability to interact with biological systems at the cellular and molecular levels enables targeted treatments. Understanding the biodistribution of nanoparticles at the cellular level within whole organisms is crucial for assessing their safety and effectiveness; however, proper technologies have been lacking to achieve this. For example, traditional imaging techniques like magnetic resonance imaging (MRI) and computed tomography (CT) often lack the resolution needed, while tissue-section-based methods miss the whole-body systemic view. Recent tissue clearing methods have emerged as a promising solution for 3D visualization of nanoparticles in entire organs, as they enable cellular-level imaging of whole organisms without the need for sectioning. This review explores advancements in diverse tissue clearing techniques and their application in studying nanoparticle biodistribution, providing insights crucial for the development of nanoparticle-based therapies.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
3d Imaging ; Light‐sheet Fluorescence Microscopy ; Nanoparticles ; Tissue Clearing; Light Sheet Microscopy; Single-cell Resolution; Cancer Metastasis; Intact; Visualization; Clarity
ISSN (print) / ISBN
1613-6810
e-ISSN
1613-6829
Journal
Small
Quellenangaben
Article Number: e2410032
Publisher
Wiley
Publishing Place
Postfach 101161, 69451 Weinheim, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Grants
Fundamental Research Funds for the Central Universities
NOMIS Human Heart Atlas Project Grant
NOMIS Human Heart Atlas Project Grant