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Haller, M.J.* ; Bell, K.J.* ; Besser, R.E.J.* ; Casteels, K.* ; Couper, J.J.* ; Craig, M.E.* ; Larsson, H.E.* ; Jacobsen, L.* ; Lange, K.* ; Oron, T.* ; Sims, E.K.* ; Speake, C.* ; Tosur, M.* ; Ulivi, F.* ; Ziegler, A.-G. ; Wherrett, D.K.* ; Marcovecchio, M.L.*

ISPAD clinical practice consensus guidelines 2024: Screening, staging, and strategies to preserve beta-cell function in children and adolescents with Type 1 Diabetes.

Horm. Res. Paediatr., DOI: 10.1159/000543035 (2024)
Publ. Version/Full Text DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed.
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Publication type Article: Journal article
Document type Position paper
Keywords Screening; Stages; Preservation; Beta cell; Children; Type 1 diabetes; Multiple Islet Autoantibodies; Disease-modifying Therapy; Genetic Risk; General-population; Plasma-glucose; C-peptide; Hla-dr; Progression; Onset; Ketoacidosis
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1663-2818
e-ISSN 1663-2826
Journal Hormone Research in Paediatrics
Publisher Karger
Publishing Place Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
Grants Abbott Diabetes Care
Dexcom
Medtronic
Sanofi
DOI 10.1159/000543035
WOS ID 001410904600001
Scopus ID 85217152332
Erfassungsdatum 2025-02-14
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