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Localization and expression dynamics of an RNA Pol I core subunit in response to fasting in C. elegans.
MicroPubl. Biol. 2025, DOI: 10.17912/micropub.biology.001472 (2025)
Nutrient availability influences ribosome biogenesis, requiring dynamic regulation of RNA Pol I activity. In C. elegans , fasting reduces pre-rRNA levels. However, whether this reduction stems from a regulation of RNA Pol I expression remains unclear. Here, we examined how the nutritional status affects the localization and expression levels of RPOA-2 , a core subunit of RNA Pol I, in the intestine. We found that RPOA-2 retains its nucleolar localization regardless of animals being fed, fasted or fed after fasting. Interestingly, fasting reduces RPOA-2 protein amounts which are restored upon feeding. These findings suggest that the availability of RNA Pol I core subunits contributes to the regulation of rDNA transcription in response to nutrients.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2025
HGF-reported in Year
2025
ISSN (print) / ISBN
2578-9430
e-ISSN
2578-9430
Journal
microPublication biology
Quellenangaben
Volume: 2025
Publishing Place
Pasadena, CA
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-554900-001
G-554400-001
G-554400-001
PubMed ID
39975508
Erfassungsdatum
2025-03-17