PuSH - Publication Server of Helmholtz Zentrum München

Moreno Velásquez, I.* ; Peters, S.A.E.* ; Dragano, N.* ; Greiser, K.H.* ; Dörr, M.* ; Fischer, B.* ; Berger, K.* ; Hannemann, A.* ; Schnabel, R.B.* ; Nauck, M.* ; Göttlicher, S. ; Rospleszcz, S. ; Willich, S.N.* ; Krist, L.* ; Schulze, M.B.* ; Günther, K.* ; Brand, T.* ; Schikowski, T.* ; Emmel, C.* ; Schmidt, B.* ; Michels, K.B.* ; Mikolajczyk, R.* ; Kluttig, A.* ; Harth, V.* ; Obi, N.* ; Castell, S.* ; Klett-Tammen, C.J.* ; Lieb, W.* ; Becher, H.* ; Winkler, V.* ; Minnerup, H.* ; Karch, A.* ; Meinke-Franze, C.* ; Leitzmann, M.* ; Stein, M.J.* ; Bohn, B.* ; Schöttker, B.* ; Trares, K.* ; Peters, A. ; Pischon, T.*

Sex differences in the relationship of socioeconomic position with cardiovascular disease, cardiovascular risk factors, and estimated cardiovascular disease risk: Results of the German National Cohort.

J. Am. Heart Assoc. 14:e038708 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Using data from the largest German cohort study, we aimed to investigate sex differences in the relationship of socioeconomic position (SEP) with cardiovascular disease (CVD), CVD risk factors, and estimated CVD risk. METHODS AND RESULTS: A total of 204 780 (50.5% women) participants from the baseline examination of the population-based NAKO (German National Cohort) were included. Logistic, multinomial, and linear regression models were used to estimate sex-specific odds ratios (ORs) and β coefficients with 95% CIs of CVD, CVD risk factors, and very high-risk score (Systemic Coronary Risk Estimation-2) for CVD associated with SEP. Women-to-men ratios of ORs (RORs) with 95% CIs were estimated. In women compared with men, low versus high SEP (educational attainment and relative income) was more strongly associated with myocardial infarction, hypertension, obesity, overweight, elevated blood pressure, antihypertensive medication, and current alcohol consumption, but less strongly with current and former smoking. In women with the lowest versus highest educational level, the OR for a very high 10-year CVD risk was 3.61 (95% CI, 2.88-4.53) compared with 1.72 (95% CI, 1.51-1.96) in men. The women-to-men ROR was 2.33 (95% CI, 1.78-3.05). For the comparison of low versus high relative income, the odds of having a very high 10-year CVD risk was 2.55 (95% CI, 2.04-3.18) in women and 2.25 (95% CI, 2.08-2.42) in men (women-to-men ROR, 1.31 [95% CI, 1.05-1.63]). CONCLUSIONS: In women and men, there was an inverse relationship between indicators of SEP and the likelihood of having several CVD risk factors and a very high 10-year CVD risk. This association was stronger in women, suggesting that CVD risk is more strongly influenced by SEP in women compared with men.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cardiovascular Disease ; Cardiovascular Risk ; Educational Attainment ; Income ; Socioeconomic Position; European-society; Determinants; Guidelines; Cardiology; Gnc
e-ISSN 2047-9980
Journal Journal of the American Heart Association
Quellenangaben Volume: 14, Issue: 5, Pages: , Article Number: e038708 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants Dutch Organization for Health Research and Development (ZonMw)
Leibniz Association
Helmholtz Association
Federal Ministry of Education and Research