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Basophil activation test in Hymenoptera venom allergy.
Allergologie 48, 84-90 (2025)
Systemic reactions to Hymenoptera venoms require an allergological work-up before starting venom specific immunotherapy (VIT) in order to prove an IgE-mediated reaction and identify the culprit insect venom. In addition to skin tests and the determination of specific IgE antibodies, the basophil activation test (BAT) using flow cytometry has developed into a powerful test and sensitive marker for this purpose in recent years. Compared to the other tests, the BAT seems to have a better informative value in terms of clinical relevance. In Hymenoptera venom allergies, BAT is particularly useful for the diagnosis of cases with unclear or contradictory history or sensitization profile. Its results are related to adverse reactions during immunotherapy and its efficacy. They therefore have a certain predictive value for side effects and treatment success of VIT. In research, BAT is mainly used to characterize the allergenic components of Hymenoptera venoms. This review article focuses on these topics.
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Publication type
Article: Journal article
Document type
Review
Keywords
Basophil Activation Test ; Component-resolved Diagnosis ; Hymenoptera Venom Allergy ; Venom Specific Immunotherapy (vit)
ISSN (print) / ISBN
0344-5062
e-ISSN
0344-5062
Journal
Allergologie
Quellenangaben
Volume: 48,
Issue: 2,
Pages: 84-90
Publisher
Dustri
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)