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Type of diet has no major influence on inflammatory response in a Saddleback pig model.
Sci. Rep. 15:8381 (2025)
Fermentable carbohydrates and resulting short-chain fatty acids (SCFAs) received attention via modifying potential on obesity-associated systemic low-grade inflammation. However, their effects on inflammation remain poorly understood. In this study, the anti-inflammatory properties of pectin or inulin supplementation were investigated in an atherogenic-fed pig obesity model. Pigs were divided into three atherogenic-fed groups with or without 5% pectin/inulin supplementation (AD, ADp, ADi, n = 10) and a conventional-fed group (CD, n = 10) for a 15-week feeding period. We demonstrated that faecal SCFA concentrations decreased and faecal pH increased in all groups over the feeding period (P < 0.05). SCFA concentrations were comparable between colon and faeces in all groups. Liver inflammatory-marker expressions were on average < 1 in all groups, except TNF-α (AD < CD and ADi; P < 0.01). Inflammatory-marker expressions in abdominal adipose tissue exceeded subcutaneous marker expressions in all groups. AD showed significantly lower IL-1β and CD68 mRNA levels than CD (P < 0.03). Comparing the atherogenic diet groups, the IL-1β mRNA levels were higher in ADi versus AD and ADp (P = 0.02). Our data indicated that fermentable carbohydrates added to an atherogenic diet cannot resolve low-grade adipose tissue inflammatory associated with obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Inflammation ; Inulin ; Obesity ; Pectin ; Short-chain Fatty Acids; Chain Fatty-acids; Adipose-tissue; Gut Microbiota; Animal-models; Antiinflammatory Properties; Fecal Water; Obesity; Expression; Genes; Infiltration
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Journal
Scientific Reports
Quellenangaben
Volume: 15,
Issue: 1,
Article Number: 8381
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
German Federal Ministry of Research and Education (Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig)
Projekt DEAL
Projekt DEAL