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Raster Scan optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review.
Diabetes Res. Clin. Pract. 222:112095 (2025)
Diabetes mellitus (DM) may lead to microvascular and macrovascular complications. Screening for these complications is crucial and non-invasive methods with high-dissemination potential are needed. Diabetic peripheral neuropathy (DPN) is particularly challenging to screen due to the lack of reliable clinical markers and endpoints. In this context, Raster Scan Optoacoustic Mesoscopy (RSOM) emerges as a highly promising technique that offers hybrid, non-invasive imaging of optical absorption using light-induced ultrasound waves within tissue without the use of contrast agents. RSOM provides high-resolution visualisation of micro-vasculature, other tissue structures and functional information. The technique has already assessed microvasculature loss as a function of diabetes progression and used it to characterise DPN severity. RSOM has also shown that cutaneous vessels in the mesoscopic range (mean diameters of 30-40 µm) are most prominently affected by DM and that the mean number of cutaneous vessels was lower in subjects with DM than in healthy participants (p < 0.001 and p < 0.05, respectively). Although experience is still limited, we present an overview of the novel technique in relation to its potential for detecting early DM onset and development of mircovascular complications.
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Publication type
Article: Journal article
Document type
Review
Keywords
Diabetes ; Diabetic Peripheral Neuropathy ; Microvascular Complications ; Microvasculature ; Optoacoustic Imaging ; Raster Scan Optoacoustic Mesoscopy; Tomography; Neuropathy; Dysfunction; Ultrasound; Microscopy; Microcirculation; Oxygenation; Metabolism; Frequency
ISSN (print) / ISBN
0168-8227
e-ISSN
1872-8227
Quellenangaben
Volume: 222,
Article Number: 112095
Publisher
Elsevier
Publishing Place
Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
European Union