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Campbell, S.J.* ; Utinger, B.* ; Barth, A.* ; Leni, Z.* ; Zhang, Z.H.* ; Resch, J.* ; Li, K.* ; Steimer, S.S.* ; Banach, C.* ; Gfeller, B.* ; Wragg, F.P.H.* ; Westwood, J.* ; Wolfer, K.* ; Bukowiecki, N.* ; Ihalainen, M.* ; Yli-Pirilä, P.* ; Somero, M.* ; Kortelainen, M.* ; Louhisalmi, J.* ; Sklorz, M. ; Czech, H. ; Di Bucchianico, S. ; Streibel, T. ; Delaval, M.N. ; Rüger, C.* ; Baumlin, N.* ; Salathe, M.* ; Fang, Z.* ; Pardo, M.* ; D'Aronco, S.* ; Giorio, C.* ; Shi, Z.* ; Harrison, R.M.* ; Green, D.C.* ; Kelly, F.J.* ; Rudich, Y.* ; Paulson, S.E.* ; Sippula, O.* ; Zimmermann, R. ; Geiser, M.* ; Kalberer, M.*

Short-lived reactive components substantially contribute to particulate matter oxidative potential.

Sci. Adv. 11:eadp8100 (2025)

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Exposure to airborne particulate matter (PM) has been attributed to millions of deaths annually. However, the PM components responsible for observed health effects remain unclear. Oxidative potential (OP) has gained increasing attention as a key property that may explain PM toxicity. Using online measurement methods that impinge particles for OP quantification within seconds, we reveal that 60 to 99% of reactive oxygen species (ROS) and OP in secondary organic aerosol and combustion-generated PM have a lifetime of minutes to hours and that the ROS activity of ambient PM decays substantially before offline analysis. This implies that current offline measurement methods substantially underestimate the true OP of PM. We demonstrate that short-lived OP components activate different toxicity pathways upon direct deposition onto reconstituted human bronchial epithelia. Therefore, we suggest that future air pollution and health studies should include online OP quantification, allowing more accurate assessments of links between OP and health effects.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Secondary Organic Aerosol; Oxygen Species Ros; Extended Follow-up; Air-pollution; Respiratory Health; Online Instrument; Direct Deposition; Particles; Exposure; Toxicity

ISSN (print) / ISBN 2375-2548

e-ISSN 2375-2548

Journal Science Advances

Quellenangaben Volume: 11, Issue: 12, Article Number: eadp8100

Publisher American Association for the Advancement of Science (AAAS)

Publishing Place Washington, DC [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Cooperation Group Comprehensive Molecular Analytics (CMA)

Grants Helmholtz International Laboratory aero HEALTH
EPSRC UKRI Postdoc guarantee funding grant
European Research Council (ERC)
Natural Environment Research Council (NERC)
Eurochamp
PhotOchemIStry, oxidative pOteNtial and tOxicity of Urban aeroSol (POISONOUS)
Supporting TAlent in ReSearch@University of Padova (STARS-StG MOCAA)
Horizon Europe Framework Program (EASVOLEE)
AXA Research Fund through a 2017- LIFE- PostDoc fellowship
Horizon 2020 project ULTRHAS
SNF