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In-cell architecture of the mitochondrial respiratory chain.
Science 387, 1296-1301 (2025)
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, working in concert to transfer electrons and pump protons. The precise organization of these complexes in native cells is debated. We used in situ cryo-electron tomography to visualize the native structures and organization of several major mitochondrial complexes in Chlamydomonas reinhardtii cells. ATP synthases and respiratory complexes segregate into curved and flat crista membrane domains, respectively. Respiratory complexes I, III, and IV assemble into a respirasome supercomplex, from which we determined a native 5-angstrom (Å) resolution structure showing binding of electron carrier cytochrome c. Combined with single-particle cryo-electron microscopy at 2.4-Å resolution, we model how the respiratory complexes organize inside native mitochondria.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cytochrome-c-oxidase; Complex-i; Electron-microscopy; Coupling Mechanism; Atp Synthase; Situ; Supercomplex; Phosphorylation; Visualization; Organization
Language
english
Publication Year
2025
HGF-reported in Year
2025
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 387,
Issue: 6740,
Pages: 1296-1301
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status
Peer reviewed
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-530006-001
Grants
University of Basel Biozentrum
ERC consolidator grant
SNSF Ambizione grant
Swiss Postdoctoral Fellowship
Swiss National Science Foundation
ERC consolidator grant
SNSF Ambizione grant
Swiss Postdoctoral Fellowship
Swiss National Science Foundation
WOS ID
001500662800032
PubMed ID
40112058
Erfassungsdatum
2025-05-09