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Wu, J.* ; Liu, Y.* ; Su, J.* ; Yang, Y.* ; Deng, H.* ; Yanglan, M.* ; Wu, X.* ; Luo, S. ; Liao, Y.* ; Wang, L.*

Investigation on Klebsiella pneumoniae in the field of extracellular vesicles.

Interdisc. Med., DOI: 10.1002/INMD.20240081 (2025)
Publ. Version/Full Text DOI
Open Access Gold
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Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital-acquired pneumonia. The alarming rate of serious infections and associated mortality renders KP a significant public health threat. Extracellular vesicles (EVs) are pivotal in KP's physiological and pathological mechanisms, facilitating material and information transfer and mediating interactions between the bacteria and the host. The critical role of EVs enhances our understanding of KP pathophysiology, disease progression, and strategies for infection control. This review emphasizes the mechanics of KP's antibiotic resistance and the instrumental role of EVs in the bacterium-host interplay, proposing EVs as a promising research focus for advancing KP diagnosis, therapy, and prevention.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Antibiotic Resistance ; Extracellular Vesicles ; Klebsiella Pneumoniae ; Pneumonia ; Vaccines ; Virulence
ISSN (print) / ISBN 2832-6237
e-ISSN 2832-6245
Journal Interdisciplinary Medicine
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
Grants Youth Innovation Talent Project of Ordinary university in Guangdong Province
Open Project of Guangzhou Medical University
Natural Science Foundation of Guangdong Province
National Natural Science Foundation of China
Department of Education of GuangDong Province
Science and Technology Plan Project of Guangzhou
Open Project of Guangzhou Medical University, the Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases