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Meghji, J.* ; Auld, S.C.* ; Bisson, G.P.* ; Khosa, C.* ; Masekela, R.* ; Navuluri, N.* ; Rachow, A.

Post-tuberculosis lung disease: towards prevention, diagnosis, and care.

Lancet Resp. Med. 13, 460-472 (2025)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
There is a growing body of data describing the high burden of respiratory sequelae seen among tuberculosis survivors, including children, adolescents, and adults. This group of sequelae are known as post-tuberculosis lung disease and include parenchymal damage, airway disease, and pulmonary vascular disease. It is thought that approximately half of pulmonary tuberculosis survivors have ongoing structural pathology, lung function impairment, or respiratory symptoms after the resolution of active disease. Post-tuberculosis lung disease has been associated with adverse patient outcomes, including persistent symptoms and functional impairment, ongoing health seeking, and impacts on income and employment. There is still much to understand about the epidemiology and nature of post-tuberculosis lung disease, but in this Review we focus on strategies for prevention, diagnosis, and care to inform the ongoing work of tuberculosis-affected communities, health-care providers, researchers, and policy makers. We summarise recent data, highlight evidence gaps, and suggest key research priorities for those working in the field.
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Publication type Article: Journal article
Document type Review
Keywords Pulmonary Tuberculosis; Tb; Health; Rehabilitation; Interventions; Chemotherapy; Prevalence; Mortality; Burden; Adults
ISSN (print) / ISBN 2213-2600
Journal Lancet Respiratory Medicine, The
Quellenangaben Volume: 13, Issue: 5, Pages: 460-472 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Research Unit Global Health (UGH)
Grants US National Institutes of Health
UK Government
UK National Institute for Health and Care Research