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Chakravartti, S.P.* ; Jann, K.* ; Veit, R. ; Liu, H.* ; Yunker, A.G.* ; Angelo, B.* ; Monterosso, J.R.* ; Xiang, A.H.* ; Kullmann, S. ; Page, K.A.*

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.

Nat. Metab. 7, 574-585 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Sucralose, a widely used non-caloric sweetener, provides sweet taste without calories. Some studies suggest that non-caloric sweeteners stimulate appetite, possibly owing to the delivery of a sweet taste without the post-ingestive metabolic signals that normally communicate with the hypothalamus to suppress hunger. In a randomized crossover trial (ClinicalTrials.gov identifier: NCT02945475 ), 75 young adults (healthy weight, overweight or with obesity) consumed a drink containing sucralose, sweetness-matched sucrose or water. We show that acute consumption of sucralose versus sucrose stimulates hypothalamic blood flow (P < 0.018) and greater hunger responses (P < 0.001). Sucralose versus water also increases hypothalamic blood flow (P < 0.019) but produces no difference in hunger ratings. Sucrose, but not sucralose, increases peripheral glucose levels, which are associated with reductions in medial hypothalamic blood flow (P < 0.007). Sucralose, compared to sucrose and water, results in increased functional connections between the hypothalamus and brain regions involved in motivation and somatosensory processing. These findings suggest that non-caloric sweeteners could affect key mechanisms in the hypothalamus responsible for appetite regulation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Low-calorie Sweeteners; Human Hypothalamic Responses; High-intensity Sweeteners; Nonnutritive Sweeteners; Functional Connectivity; Insulin Sensitivity; Menstrual-cycle; Blood-flow; Glucose; Consumption
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Quellenangaben Volume: 7, Issue: 3, Pages: 574-585 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants Diabetes and Obesity Research Institute of the University of Southern California
Southern California Clinical and Translational Science Institute through NIH
National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
DOI 10.1038/s42255-025-01227-8
WOS ID 001454471800003
Scopus ID 105001338914
PubMed ID 40140714
Erfassungsdatum 2025-05-09
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