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Grunewald, T.G.* ; Ranft, A.* ; Esposito, I. ; Da Silva-Buttkus, P. ; Aichler, M. ; Baumhoer, D.* ; Schaefer, K.L.* ; Ottaviano, L.* ; Poremba, C.* ; Jundt, G.* ; Jürgens, H.* ; Dirksen, U.* ; Richter, G.H.* ; Burdach, S.*

High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients.

Ann. Oncol. 23, 2185-2190 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Ewing's sarcoma (ES) is the second most common bone or soft-tissue sarcoma in childhood and adolescence and features a high propensity to metastasize. The six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is a membrane-bound mesenchymal stem cell marker highly expressed in ES. Here, we investigated the role of STEAP1 as an immunohistological marker for outcome prediction in patients with ES. PATIENTS AND METHODS: Membranous STEAP1 immunoreactivity was analyzed using immunohistochemistry in 114 primary pre-chemotherapy ES of patients diagnosed from 1983 to 2010 and compared with clinical parameters and patient outcome. Median follow-up was 3.85 years (range 0.43-17.51). RESULTS: A total of 62.3% of the ES samples displayed detectable STEAP1 expression with predominant localization of the protein at the plasma membrane. High membranous STEAP1 immunoreactivity was found in 53.5%, which correlated with better overall survival (P = 0.021). Accordingly, no or low membranous STEAP1 expression was identified as an independent risk factor in multivariate analysis (hazard ratio 2.65, P = 0.036). CONCLUSIONS: High membranous STEAP1 expression predicts improved outcome and may help to define a specific subgroup of ES patients, who might benefit from adapted therapy regimens.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords biomarker; Ewing's sarcoma; outcome; risk stratification; STEAP1; 6-transmembrane Epithelial Antigen ; Long-term Survival ; Stem-cell Rescue ; Breast-cancer ; Nuclear-localization ; Prognostic-factors ; Tumor Patients ; Family Tumors ; Prostate ; Growth
ISSN (print) / ISBN 0923-7534
e-ISSN 1569-8041
Journal Annals of Oncology
Quellenangaben Volume: 23, Issue: 8, Pages: 2185-2190 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)