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Open Access Green as soon as Postprint is submitted to ZB.
Evaluation of the sysmex CN-6000 coagulation analyzer for routine and specialized coagulation testing in a central laboratory.
Clin. Lab. 71, 493-501 (2025)
Background: The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital. Methods: The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials. Patient plasma samples were used to compare results of coagulation measurements between the Sysmex CN-6000 and the Atellica COAG 360, including plasma samples with visual interference. The sample throughputs of both analyzers were compared using plasma samples from healthy volunteers. Results: Within- and between-day coefficients of variation were acceptable for all assays tested on the Sysmex CN6000. High correlation and good agreement were observed when comparing coagulation results from the Sysmex CN-6000 and the Atellica COAG 360. Samples with visual interference showed comparable coagulation results between the two analyzers, with slightly better detection by the Sysmex CN-6000. The sample throughput per hour for analysis of a panel of five coagulation parameters was higher with the Sysmex CN-6000 compared to the Atellica COAG 360 (247 vs. 193 tests). Conclusions: The Sysmex CN-6000 demonstrated excellent analytical performance for a large number of coagulation parameters and has a high throughput capacity, ideal for the needs of a central laboratory with a high volume of routine and specialized coagulation testing. (Clin. Lab. 2025;71:493-501. DOI: 10.7754/Clin.Lab.2024.240922)
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
hemostasis; coagulation; core laboratory; throughput; HIL check; Hemostasis
ISSN (print) / ISBN
1433-6510
Journal
Clinical Laboratory
Quellenangaben
Volume: 71,
Issue: 3,
Pages: 493-501
Publisher
Clinical Laboratory Publ.
Publishing Place
Mainz
Non-patent literature
Publications
Reviewing status
Peer reviewed