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Open Access Green as soon as Postprint is submitted to ZB.
Epigenome dynamics in early mammalian embryogenesis.
Nat. Rev. Genet. 26, 587–603 (2025)
During early embryonic development in mammals, the totipotency of the zygote - which is reprogrammed from the differentiated gametes - transitions to pluripotency by the blastocyst stage, coincident with the first cell fate decision. These changes in cellular potency are accompanied by large-scale alterations in the nucleus, including major transcriptional, epigenetic and architectural remodelling, and the establishment of the DNA replication programme. Advances in low-input genomics and loss-of-function methodologies tailored to the pre-implantation embryo now enable these processes to be studied at an unprecedented level of molecular detail in vivo. Such studies have provided new insights into the genome-wide landscape of epigenetic reprogramming and chromatin dynamics during this fundamental period of pre-implantation development.
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Publication type
Article: Journal article
Document type
Review
Keywords
Zygotic Genome Activation; Cell Nuclear Transfer; To-embryo Transition; Novo Dna Methylation; Gene-expression; Mouse Embryos; Constitutive Heterochromatin; Chromatin Architecture; Rna Modifications; Transcription
ISSN (print) / ISBN
1471-0056
e-ISSN
1471-0064
Journal
Nature Reviews - Genetics
Quellenangaben
Volume: 26,
Pages: 587–603
Publisher
Nature Publishing Group
Publishing Place
Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
Grants
National Institutes of Health 4DN programme
German Research Council
Helmholtz Association
German Research Council
Helmholtz Association