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Carli, G.* ; Dortmond, A.* ; Janzen, A.* ; Sittig, E.* ; De Meyer, E.* ; Leenders, K.L.* ; Oertel, W.H. ; Meles, S.K.*

Parkinson's Disease-Related pattern in isolated REM sleep behaviour disorder as a prodromal progression marker: 8-Year Follow-Up changes assessed at three time points.

Eur. J. Nucl. Med. Mol. Imaging, DOI: 10.1007/s00259-025-07260-9 (2025)
Postprint DOI PMC
Open Access Green
BACKGROUND: Isolated REM sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. Biomarkers are crucial for predicting and monitoring its progression, warranting long-term neuroimaging studies. While the Parkinson's Disease Related Pattern (PDRP) from 18F-FDG PET is a recognized Parkinson's Disease (PD) biomarker, its role in tracking progression in prodromal PD remains unclear. OBJECTIVE: To explore PDRP expression across three time points using 18F-FDG PET over an 8-year follow-up in iRBD. METHODS: Thirteen iRBD subjects underwent 18F-FDG PET brain scans at baseline (BL), follow-up 1 (FU1, 4 years), and follow-up 2 (FU2, 8 years). Among them, four developed PD, one Dementia with Lewy Bodies (DLB), three showed subthreshold parkinsonism, and five showed no progression. PDRP z-scores were analyzed within and between groups (converters vs. non-converters) using a two-way repeated measures ANOVA. Similar analyses were conducted for motor scores (Unified Parkinson's Disease Rating Scale part three, UPDRS-III). RESULTS: There was a significant main effect of group (p = 0.011), time (p < 0.001), and a group*time interaction (p = 0.020), indicating that while PDRP z-scores increased over time in most iRBD subjects, the increase was more pronounced in converters (n = 5) than in non-converters (n = 8). Post-hoc tests revealed significantly higher PDRP z-scores in converters compared to non-converters at FU1 (p = 0.042) and FU2 (p = 0.024). For UPDRS-III scores we found significant effects of group (p = 0.011), time (p < 0.001), and their interaction (p = 0.0003). CONCLUSIONS: Repeated 18F-FDG PET scans may be useful to monitor prodromal disease progression and predict conversion in iRBD patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 18f-fdg Pet ; Pdrp ; Brain Glucose Metabolism ; Disease Progression ; Irbd; Metabolic Network Activity; Criteria
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1619-7070
e-ISSN 1432-105X
Journal European Journal of Nuclear Medicine and Molecular Imaging
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503200-001
Grants Michael J. Fox Foundation (Edmond J. Safra Fellowship in Movement Disorders)
Charitable Hertie Foundation, Frankfurt/Main, Germany
German "ParkinsonFonds Deutschland"
Dutch "Stichting ParkinsonFonds"
DOI 10.1007/s00259-025-07260-9
WOS ID 001462218500001
Scopus ID 105002161929
PubMed ID 40192791
Erfassungsdatum 2025-05-10
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