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Freibothe, I.* ; Müller, T.D.

Inkretine als Grundlage der Adipositastherapie.

Incretins as the basis of obesity treatment.

Innere Med. 66, 461-466 (2025)
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Obesity represents an immense challenge for patients and physicians due to its numerous comorbidities and complications. For a long time, safe and effective pharmacological treatment remained wishful thinking. Bariatric surgery was considered the only option for sustained weight loss; however, with the advent of incretin-based treatment, initially introduced as a highly effective component of anti-diabetic treatment, research began to focus on the complex gastroenteropancreatic endocrine system, including central hunger and satiety regulation. This shift was driven by the discovery of a remarkable side effect: placebo-controlled weight reduction. Subsequent groundbreaking pharmacological developments based on long-acting peptides, the administration of which could be reduced from twice daily in earlier forms of treatment to once weekly, now enables significant weight reduction of over 20%, with a tolerable safety profile. This article provides an illustrative overview of the corresponding associations and highlights this milestone in obesity treatment.
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Publication type Article: Journal article
Document type Review
Keywords Appetite Regulation ; Glucagon-like Peptide 1 (glp-1) ; Glucose-dependent Insulinotropic Polypeptide (gip) ; Obesity/drug Therapy ; Weight Loss; Appetite
Language german
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2731-7080
e-ISSN 2731-7099
Journal Innere Medizin
Quellenangaben Volume: 66, Issue: 5, Pages: 461-466 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelbergerplatz 3, Berlin, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-221
DOI 10.1007/s00108-025-01893-6
WOS ID 001464600300001
Scopus ID 105002290744
PubMed ID 40210769
Erfassungsdatum 2025-05-10
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