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Horvath, P. ; Coscia, F.*

Spatial proteomics in translational and clinical research.

Mol. Syst. Biol., DOI: 10.1038/s44320-025-00101-9 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Spatial proteomics offers unprecedented insights into the localization, quantity, and interactions of proteins within cells and tissues, thereby enabling researchers and clinicians to map protein networks with high precision. This powerful approach is currently revolutionizing our understanding of cellular organization and function (Method of the Year 2024: spatial proteomics, 2024), and providing deeper insights into how protein distribution and dynamics contribute to physiological and pathological processes. Here, we discuss recent advances in targeted and untargeted (exploratory) spatial proteomics, shed light on emerging multiscale approaches for tissue profiling, and highlight their translational potential.
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Publication type Article: Journal article
Document type Editorial
Corresponding Author
ISSN (print) / ISBN 1744-4292
e-ISSN 1744-4292
Journal Molecular Systems Biology
Publisher EMBO Press
Publishing Place Campus, 4 Crinan St, London, N1 9xw, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of AI for Health (AIH)
Grants European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program
Horizon-BIALYMPH (NRDIO)
Horizon-SYMMETRY (NRDIO)
Horizon-SWEEPICS
H2020-Fair-CHARM
HAS-NAP3
NKKP-ADVANCED
Finnish Cancer Society (Cancer Foundation Finland)
Federal Ministry of Education and Research (BMBF), as part of the National Research Initiatives for Mass Spectrometry in Systems Medicine
National Research, Development and Innovation Office