PuSH - Publication Server of Helmholtz Zentrum München: A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Scherer, T.* ; Metz, M.* ; Beghini, M.* ; Bilban, M.* ; Gensthaler, L.* ; Luca, A.C.* ; Kaplanian, M.* ; Abu Eid, S.* ; Koldyka, O.* ; Hackl, M.T.* ; Dürr, S.* ; Rivelles, E.* ; Schönecker, S.S.* ; Pöltl, L.* ; Kaya, A.* ; Chami, R.* ; Nusko, L.* ; Tschare, C.* ; Ablaza, K.* ; Höbler, A.L.* ; Klimek, P.* ; Leutner, M.* ; Yamamoto, M.* ; Suzuki, N.* ; Stemmer, K. ; Zeyda, M.* ; Steinacher, D.* ; Nics, L.* ; Müller, A.M.S.* ; Helbich, T.H.* ; Moriggl, R.* ; Kautzky-Willer, A.* ; Windberger, U.* ; Prager, G.* ; Fürnsinn, C.*

A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice.

Sci. Adv. 11:eadt7366 (2025)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained under hypoxia exhibit a delayed but distinct decrease in blood glucose with improved insulin sensitivity, which is independent of changes in body weight. This effect of hypoxia is mediated by erythropoiesis and is a direct result of the rising hematocrit, which could be due to erythrocytes acting as carriers of glucose units in the blood. Glucose lowering by the red cell mass is evidenced by a prompt decrease in glycemia in mice receiving a blood transfusion. Furthermore, life under hypoxia as well as treatment with erythropoietin reduce glycemia also in mice expressing the erythropoietin receptor exclusively in hematopoietic cells, which contrasts with previous assumptions attributing metabolic actions of erythropoietin to direct action on nonhematopoietic tissues. Our results provide a rationale for associations between hematocrit and blood glucose in humans under anti-anemic therapy, polycythemia, smoking, and high-altitude exposure.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Recombinant-human-erythropoietin; Inverse Association; Insulin Sensitivity; High-altitude; Homeostasis; Testosterone; Performance; Expression; Obesity; Diet

ISSN (print) / ISBN 2375-2548

e-ISSN 2375-2548

Journal Science Advances

Quellenangaben Volume: 11, Issue: 16, Article Number: eadt7366

Publisher American Association for the Advancement of Science (AAAS)

Publishing Place Washington, DC [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)

Grants Skolkovo (Moskow School of Management, Russia)
Austrian Science Fund (FWF)