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Xiong, Y.* ; Knoedler, S. ; Alfertshofer, M.* ; Kim, B.S.* ; Jiang, D.* ; Liu, G.* ; Rinkevich, Y. ; Mi, B.*

Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: A narrative review.

Cell Death Dis. 16:341 (2025)

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Metabolic aberrations are fundamental to the complex pathophysiology and challenges associated with diabetic wound healing. These alterations, induced by the diabetic environment, trigger a cascade of events that disrupt the normal wound-healing process. Key factors in this metabolic alternation include chronic hyperglycemia, insulin resistance, and dysregulated lipid and amino acid metabolism. In this review, we summarize the underlying mechanisms driving these metabolic changes in diabetic wounds, while emphasizing the broad implications of these disturbances. Additionally, we discuss therapeutic approaches that target these metabolic anomalies and how their integration with existing wound-healing treatments may yield synergistic effects, offering promising avenues for innovative therapies.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Insulin-resistance; Oxidative Stress; Injury Model; Hydrogel; Obesity; Promotes; Glucose; Repair; Inhibition; Inflammation

ISSN (print) / ISBN 2041-4889

e-ISSN 2041-4889

Journal Cell Death & Disease

Quellenangaben Volume: 16, Issue: 1, Article Number: 341

Publisher Nature Publishing Group

Publishing Place Campus, 4 Crinan St, London, N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Regenerative Biology and Medicine (IRBM)

Grants European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Program
LEO Foundation
European Research Council
China Postdoctoral Science Foundation
NSFC
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)