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Xiong, Y.* ; Knoedler, S. ; Alfertshofer, M.* ; Kim, B.S.* ; Jiang, D.* ; Liu, G.* ; Rinkevich, Y. ; Mi, B.*

Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: A narrative review.

Cell Death Dis. 16:341 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Metabolic aberrations are fundamental to the complex pathophysiology and challenges associated with diabetic wound healing. These alterations, induced by the diabetic environment, trigger a cascade of events that disrupt the normal wound-healing process. Key factors in this metabolic alternation include chronic hyperglycemia, insulin resistance, and dysregulated lipid and amino acid metabolism. In this review, we summarize the underlying mechanisms driving these metabolic changes in diabetic wounds, while emphasizing the broad implications of these disturbances. Additionally, we discuss therapeutic approaches that target these metabolic anomalies and how their integration with existing wound-healing treatments may yield synergistic effects, offering promising avenues for innovative therapies.
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Publication type Article: Journal article
Document type Review
Keywords Insulin-resistance; Oxidative Stress; Injury Model; Hydrogel; Obesity; Promotes; Glucose; Repair; Inhibition; Inflammation
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2041-4889
e-ISSN 2041-4889
Journal Cell Death & Disease
Quellenangaben Volume: 16, Issue: 1, Pages: , Article Number: 341 Supplement: ,
Publisher Nature Publishing Group
Publishing Place Campus, 4 Crinan St, London, N1 9xw, England
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
Grants European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Program
LEO Foundation
European Research Council
China Postdoctoral Science Foundation
NSFC
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
DOI 10.1038/s41419-025-07583-3
WOS ID 001476779000004
Scopus ID 105003677295
PubMed ID 40280905
Erfassungsdatum 2025-05-10
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