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Closed: Publ. Version/Full Text online available 05/2026
as soon as is submitted to ZB.
Stem cells as role models for reprogramming and repair.
Science 388:eadp2959 (2025)
Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decades. This ability is currently being exploited for therapies using strategies to repair or replace damaged tissues and cells or to alleviate immune rejection. Exploring stem cell function has enabled direct reprogramming approaches, for example, through the production of induced pluripotent stem cells and the generation of tissue-specific stem cells. Understanding stem cell function has emerged as an important strategy for repopulating stem cell pools or generating differentiated cells for therapy. Here, we review general principles of mammalian stem cell biology and cellular reprogramming approaches and their use for current and future therapeutic purposes.
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Publication type
Article: Journal article
Document type
Review
Keywords
Neural Stem; Mouse Fibroblasts; Direct Conversion; Adult Brain; Neurons; Liver; Regeneration; Identification; Quiescence; Astrocytes
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 388,
Issue: 6746,
Article Number: eadp2959
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status
Peer reviewed
Grants
German Research Foundation
German Research Foundation (SyNergy project)
European Union (NSC Reconstruct project)
Helmholtz Association
German Research Foundation (SyNergy project)
European Union (NSC Reconstruct project)
Helmholtz Association