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Hoffmann, G.V.* ; Gottschlich, A.* ; Subklewe, M.* ; Kobold, S.

Novel approaches to CAR T cell target identification in acute myeloid leukemia.

Curr. Opin. Pharmacol. 82:102524 (2025)
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Identifying safe and effective CAR T cell targets in acute myeloid leukemia (AML) is challenging due to the disease's complexity and overlap with normal hematopoiesis. This review highlights advances in target discovery for AML, emphasizing innovative approaches. Structural surfaceomics identifies tumor-specific protein conformations, while AI-driven single-cell RNA sequencing integrates multi-source data to pinpoint optimal targets. Refined cell surface capture technology maps the AML surfaceome without relying on predefined antibodies. These strategies enhance CAR T cell specificity and minimize off-tumor effects, offering promising pathways for safer and more effective AML treatments and broader cancer therapies.
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Publication type Article: Journal article
Document type Review
Keywords Stem-cells; Antibody; Therapy; Heterogeneity; Expression; Ozogamicin; Cultures; Cancer
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Journal Current opinion in pharmacology
Quellenangaben Volume: 82, Issue: , Pages: , Article Number: 102524 Supplement: ,
Publisher Elsevier
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Unit for Clinical Pharmacology (KKG-EKLiP)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-522100-001
Grants Bavarian Research Foundation (BAYCELLATOR)
Marie Sklodowska-Curie Training Network for Optimizing Adoptive T Cell Therapy of Cancer - Horizon 2020 programme of the European Union
German Cancer Aid
Wilhelm-Sander-Stiftung
Ernst Jung Stiftung
Institutional Strategy LMUexcellent of LMU Munich
Bavarian Ministry for Economical Affairs
Bundesministerium fur Bildung und Forschung
European Research Council
Deutsche Forschungsgemeinschaft (DFG)
Fritz-Bender Foundation
Monika-Kutzner Foundation for Cancer Research
Horizon 2020 programme of the European Union
DOI 10.1016/j.coph.2025.102524
WOS ID 001494569300001
Scopus ID 105003924259
PubMed ID 40311558
Erfassungsdatum 2025-05-11
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