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Genetics of restless legs syndrome: Insights from genome-wide association studies.
Sleep Med. Clin. 20, 193-202 (2025)
Genome-wide association studies (GWAS) of common and low-frequency variants have discovered 164 genetic risk loci for restless legs syndrome (RLS) in adult populations of European ancestry. Sex-specific GWAS meta-analyses revealed largely overlapping genetic risk profiles for women and men and are in line with a nongenetic risk factor driving the higher prevalence seen in women. Genetic investigations of pediatric RLS are limited, but the likely inclusion of early-onset cases in GWAS of adult populations and the similar phenotypic presentation of both forms suggest that genetic risk variants identified in adult populations transfer to pediatric RLS.
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Publication type
Article: Journal article
Document type
Review
Keywords
Gwas ; Genetic Architecture ; Genome-wide Association Study ; Meta-analysis ; Polygenic Risk Score ; Rls ; Restless Legs Syndrome; Diagnostic-criteria; Childhood-onset; Complex; Risk; Age; Locus; Polygenicity; Heritability; Architecture; Variants
ISSN (print) / ISBN
1556-407X
e-ISSN
1556-4088
Journal
Sleep Medicine Clinics
Quellenangaben
Volume: 20,
Issue: 2,
Pages: 193-202
Publisher
Elsevier
Publishing Place
525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa
Non-patent literature
Publications
Institute(s)
Institute of Neurogenomics (ING)