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Open Access Green as soon as Postprint is submitted to ZB.
Modulation of inflammatory immune reactions by low-dose ionizing radiation: Molecular mechanisms and clinical application.
Curr. Med. Chem. 19, 1741-1750 (2012)
During the last decade, a multitude of experimental evidence has accumulated showing that low-dose radiation therapy (single dose 0.5-1 Gy) functionally modulates a variety of inflammatory processes and cellular compounds including endothelial (EC), mononuclear (PBMC) and polymorphonuclear (PMN) cells, respectively. These modulations comprise a hampered leukocyte adhesion to EC, induction of apoptosis, a reduced activity of the inducible nitric oxide synthase, and a lowered oxidative burst in macrophages. Moreover, irradiation with a single dose between 0.5-0.7 Gy has been shown to induce the expression of X-chromosome linked inhibitor of apoptosis and transforming growth factor beta 1, to reduce the expression of E-selectin and L-selectin from EC and PBMC, and to hamper secretion of Interleukin-1, or chemokine CCL20 from macrophages and PMN. Notably, a common feature of most of these responses is that they display discontinuous or biphasic dose dependencies, shared with "non-targeted" effects of low-dose irradiation exposure like the bystander response and hyper-radiosensitivity. Thus, the purpose of the present review is to discuss recent developments in the understanding of low-dose irradiation immune modulating properties with special emphasis on discontinuous dose response relationships.
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Publication type
Article: Journal article
Document type
Review
Keywords
Biphasic dose response; discontinuous dose dependency; immune modulation; inflammation; ionizing radiation; low-dose radiation therapy; NF-KAPPA-B; EA.HY.926 ENDOTHELIAL-CELLS; ADJUVANT-INDUCED ARTHRITIS; PAINFUL HEEL SPURS; BLOOD MONONUCLEAR-CELLS; TRANSFORMATION IN-VITRO; LOW-LET RADIATION; X-IRRADIATION; NEOPLASTIC TRANSFORMATION; DNA-DAMAGE
ISSN (print) / ISBN
0929-8673
e-ISSN
1875-533X
Journal
Current Medicinal Chemistry
Quellenangaben
Volume: 19,
Issue: 12,
Pages: 1741-1750
Publisher
Bentham Science Publishers
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)