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Loft, A.* ; Emont, M.P.* ; Weinstock, A.* ; Divoux, A.* ; Ghosh, A.* ; Wagner, A.* ; Hertzel, A.V.* ; Maniyadath, B.* ; Deplancke, B.* ; Liu, B.* ; Scheele, C.* ; Lumeng, C.* ; Ding, C.* ; Ma, C.* ; Wolfrum, C.* ; Strieder-Barboza, C.* ; Li, C.* ; Truong, D.D.* ; Bernlohr, D.A.* ; Stener-Victorin, E.* ; Kershaw, E.E.* ; Yeger-Lotem, E.* ; Shamsi, F.* ; Hui, H.X.* ; Camara, H.* ; Zhong, J.* ; Kalucka, J.* ; Ludwig, J.A.* ; Semon, J.A.* ; Jalkanen, J.* ; Whytock, K.L.* ; Dumont, K.D.* ; Sparks, L.M.* ; Muir, L.A.* ; Fang, L.* ; Massier, L. ; Saraiva, L.R.* ; Beyer, M.D.* ; Jeschke, M.G.* ; Mori, M.A.* ; Boroni, M.* ; Walsh, M.J.* ; Patti, M.E.* ; Lynes, M.D.* ; Blüher, M. ; Rydén, M.* ; Hamda, N.* ; Solimini, N.L.* ; Mejhert, N.* ; Gao, P.* ; Gupta, R.K.* ; Murphy, R.* ; Pirouzpanah, S.* ; Corvera, S.* ; Tang, S.* ; Das, S.K.* ; Schmidt, S.F.* ; Zhang, T.* ; Nelson, T.M.* ; O'Sullivan, T.E.* ; Efthymiou, V.* ; Wang, W.* ; Tong, Y.* ; Tseng, Y.H.* ; Mandrup, S.* ; Rosen, E.D.*

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.

Nat. Metab. 7, 875-894 (2025)
Postprint DOI PMC
Open Access Green
Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.
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Publication type Article: Journal article
Document type Review
Keywords Insulin-resistance; Regional-variation; Brown; Fat; Distinct; Beige; Gamma; Identification; Adipocytes; Reveals
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Quellenangaben Volume: 7, Issue: 5, Pages: 875-894 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506509-001
G-506501-001
Grants National Institutes of Health
Sygeforsikring 'danmark'
Lundbeck Foundation
The Danish National Research Foundation
DOI 10.1038/s42255-025-01296-9
WOS ID 001494214000001
Scopus ID 105007119898
PubMed ID 40360756
Erfassungsdatum 2025-05-15
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